Sherlock Holmes and John Watson
Friendship Type: Partners in Crime (-Solving)
Before there was Rick and Morty, there was the original dream team: the boys of 221B Baker Street. Watson thinks that Sherlock is off his rocker, and Sherlock makes fun of Watson every chance he gets (hey, who doesn’t wish they had a brilliant doctor buddy to mock as their intellectual inferior?). But when it comes down to it, these guys are fiercely loyal to one another. Without Watson, Holmes would just be a lonely genius (OK, maybe he'd be a lonely genius in prison), and Watson thrives on the daily adventure, the writing fodder, and the veritable buffet of putdowns that Sherlock provides. They're two dudes who hate crime, but love each other.